Projections: A Story of Human Emotions
Book by Karl Deisseroth
DETAILS
Publisher : Random House; First Edition (June 15, 2021) Language : English Hardcover : 256 pages ISBN-10 : 1984853694 ISBN-13 : 978-1984853691 Item Weight : 1 pounds Dimensions : 6.33 x 0.91 x 9.51 inches Best Sellers Rank: #26,906 in Books (See Top 100 in Books) #45 in Emotional Mental Health #46 in Medical Professional Biographies #88 in History & Philosophy of Science (Books) , A groundbreaking tour of the human mind that illuminates the biological nature of our inner worlds and emotions, through gripping, moving—and, at times, harrowing—clinical stories “[A] scintillating and moving analysis of the human brain and emotions.”— Nature “Beautifully connects the inner feelings within all human beings to deep insights from modern psychiatry and neuroscience.”—Robert Lefkowitz, Nobel Laureate Karl Deisseroth has spent his life pursuing truths about the human mind, both as a renowned clinical psychiatrist and as a researcher creating and developing the revolutionary field of optogenetics, which uses light to help decipher the brain’s workings. In Projections, he combines his knowledge of the brain’s inner circuitry with a deep empathy for his patients to examine what mental illness reveals about the human mind and the origin of human feelings—how the broken can illuminate the unbroken. Through cutting-edge research and gripping case studies from Deisseroth’s own patients, Projections tells a larger story about the material origins of human emotion, bridging the gap between the ancient circuits of our brain and the poignant moments of suffering in our daily lives. The stories of Deisseroth’s patients are rich with humanity and shine an unprecedented light on the self—and the ways in which it can break down. A young woman with an eating disorder reveals how the mind can rebel against the brain’s most primitive drives of hunger and thirst; an older man, smothered into silence by depression and dementia, shows how humans evolved to feel not only joy but also its absence; and a lonely Uighur woman far from her homeland teaches both the importance—and challenges—of deep social bonds. Illuminating, literary, and essential, Projections is a revelatory, immensely powerful work. It transforms our understanding not only of the brain but of ourselves as social beings—giving vivid illustrations through science and resonant human stories of our yearning for connection and meaning. Read more
REVIEW
This is an informative and engaging book by Karl Deisseroth, MD, which delves into the related worlds of psychiatry and neuroscience. He’s a master of both. A variety of patients with complex clinical symptoms are described. Among the pathologies covered are eating disorders, incipient schizophrenia, borderline personality disorder, autism and others. Dr. D leads us through the mysteries of our brains and some of its defects exhibited by these patients. He notes that the only tools psychiatrists have are the words, gestures, and actions of the patients they attempt to heal, or to at least try to attenuate the symptoms so these patients can survive. The stories of these patients are told in the context of their presentation to the psychiatric emergency department at Stanford. We travel through these cases with Karl, the residents and the fellows who assist him. The most likely original diagnosis often changes as more information is gathered. We learn about human evolution and are introduce to some of the hypotheses on why these defects have not been selected out by natural selection. Dr. Deisseroth occasionally switches to describing changes in the behaviors of mice as he identifies specific cells in areas of their brains that he activates or detunes with optogenetics, an important technology he invented. He speculates that these cell types and their connections with other areas of the brain are major players in the origin and maintenance of some of the pathologies he describes in these patients. The analogies the author employs are excellent, as are the literary references he uses. He gives us a window into himself by describing how several of the patients he encounters lead him to think about past experiences in his own full life. I typically mark important passages as I read books to facilitate reviewing them in the future. Three of the chapters have marks in 30% of the text, suggesting much of the chapters merited my rereading. One minor annoyance, which I assume was on purpose, was the lack of an “Index.” However, open-access links are included at the end for those who’d like to follow up any of the scientific ideas.
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